The following are health and medical definitions of terms that appear in the Leukemia article. Abdomen: The belly , that part of the body that contains all of the structures between the chest and the pelvis . The abdomen is separated anatomically from the chest by the diaphragm , the powerful muscle spanning the body cavity below the lungs .
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Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer ).
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Acute: Of abrupt onset, in reference to a disease. Acute often also connotes an illness that is of short duration, rapidly progressive, and in need of urgent care.
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Acute leukemia : Cancer of the white blood cells (leukemia) that characteristically comes on abruptly and, if not treated, progresses rapidly. The two major types of acute leukemia are acute lymphoblastic leukemia (ALL) and acute myelocytic leukemia ( AML ).
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Acute lymphoblastic leukemia: An acute (sudden onset), rapidly progressing form of leukemia that is characterized by the presence in the blood and bone marrow of large numbers of unusually immature white blood cells destined to become lymphocytes. Acute lymphoblastic leukemia is also called acute lymphocytic leukemia and is abbreviated ALL (spoken not as the word "all", but as the three letters A-L-L). ALL is the most common cancer occurring in children, representing almost 25% of cancer among children. There is a sharp peak in the incidence of ALL incidence among children ages 2 to 3. This peak is approximately fourfold greater than that for infants and is nearly 10-fold greater than that for youths who are 19 years old.
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Acute lymphocytic leukemia: See: Acute lymphoblastic leukemia.
Acute myelogenous leukemia : Abbreviated AML. Also called acute myeloid leukemia or acute nonlymphocytic leukemia (ANLL). A quickly progressive malignant disease in which there are too many immature blood-forming cells in the blood and bone marrow , the cells being specifically those destined to give rise to the granulocytes or monocytes , both types of white blood cells that fight infections. In AML, these blasts do not mature and so become too numerous. AML can occur in adults or children.
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Acute myeloid leukemia : A quickly progressive malignant disease in which there are too many immature blood-forming cells in the blood and bone marrow , the cells being specifically those destined to give rise to the granulocytes or monocytes , both types of white blood cells that fight infections. In AML, these blasts do not mature and so become too numerous. AML can occur in adults or children. Acute myeloid leukemia is abbreviated AML (pronounced A M L). It is also known as acute myelogenous leukemia or acute nonlymphocytic leukemia (ANLL).
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Allogeneic: Taken from different individuals of the same species. Two or more individuals are said to be allogeneic to one another when the genes at one or more loci are not identical.
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Anemia: The condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased.
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Anesthesia: Loss of feeling or awareness. A general anesthetic puts the person to sleep. A local anesthetic causes loss of feeling in a part of the body such as a tooth or an area of skin without affecting consciousness. Regional anesthesia numbs a larger part of the body such as a leg or arm, also without affecting consciousness. The term "conduction anesthesia" encompasses both local and regional anesthetic techniques. Many surgical procedures can be done with conduction anesthesia without significant pain. In many situations, such as a C-section, conduction anesthesia is safer and therefore preferable to general anesthesia. However, there are also many types of surgery in which general anesthesia is clearly appropriate.
Antibody: An immunoglobulin, a specialized immune protein , produced because of the introduction of an antigen into the body, and which possesses the remarkable ability to combine with the very antigen that triggered its production.
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Aspiration: Removal of a sample of fluid and cells through a needle. Aspiration also refers to the accidental sucking in of food particles or fluids into the lungs.
Autologous: In blood transfusion and transplantation, a situation in which the donor and recipient are the same person.
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Benzene: A sweet smelling, highly toxic hydrocarbon . Long-term exposure to benzene is known to cause anemia and leukemia . The anemia associated with benzene exposure is termed aplastic anemia . The types of leukemia associated with benzene exposure are adult acute myeloid leukemia ( AML ) and chronic lymphocytic leukemia ( CLL ). It is thought that benzene induces DNA damage in hematopoietic stem cells that give rise to leukemic clones of cells.
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Biological therapy: Treatment to stimulate or restore the ability of the immune (defense) system to fight infection and disease. Biological therapy is thus any form of treatment that uses the body's natural abilities that constitute the immune system to fight infection and disease or to protect the body from some of the side effects of treatment.
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Biopsy: The removal of a sample of tissue for purposes of diagnosis. (Many definitions of "biopsy" stipulate that the sample of tissue is removed for examination under a microscope. This may or may not be the case. The diagnosis may be achieved by other means such as by analysis of chromosomes or genes.)
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Blasts: Immature blood cells. Leukemic blasts do not grow and age normally; they proliferate wildly and fail to mature.
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Blood: The familiar red fluid in the body that contains white and red blood cells, platelets, proteins, and other elements. The blood is transported throughout the body by the circulatory system. Blood functions in two directions: arterial and venous. Arterial blood is the means by which oxygen and nutrients are transported to tissues while venous blood is the means by which carbon dioxide and metabolic by-products are transported to the lungs and kidneys, respectively, for removal from the body.
Blood-brain barrier: A protective network of blood vessels and cells that filters blood flowing to the brain.
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Board certified: Board certified in medicine means a physician has taken and passed a medical specialty examination.
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Bone: Bone is the substance that forms the skeleton of the body. It is composed chiefly of calcium phosphate and calcium carbonate . It also serves as a storage area for calcium, playing a large role in calcium balance in the blood.
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Bone marrow: The soft blood-forming tissue that fills the cavities of bones and contains fat and immature and mature blood cells, including white blood cells, red blood cells, and platelets. Diseases or drugs that affect the bone marrow can affect the total counts of these cells.
Bone marrow aspiration: The removal of a small amount of bone marrow (usually from the hip) through a needle. The needle is placed through the top layer of bone and a liquid sample containing bone marrow cells is obtained through the needle by aspirating (sucking) it into a syringe. The suction causes pain for a few moments. Bone marrow aspiration is done to diagnose and follow the progress of various conditions, including anemia and cancer , and to obtain marrow for transplantation.
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Bone marrow biopsy: The removal of a sample of bone marrow and a small amount of bone (usually from the hip) through a large needle. Two samples are taken. The first is bone marrow by aspiration (suction with a syringe). The second sample is a core biopsy to obtain bone marrow together with bone fibers. After the needle is removed, this solid sample is pushed out of the needle with a wire. Both samples are examined under a microscope to see the cells and architecture of the bone marrow.
Bone marrow transplant: A procedure in which bone marrow that is diseased or damaged is replaced with healthy bone marrow. The bone marrow to be replaced may be deliberately destroyed by high doses of chemotherapy and/or radiation therapy .
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Bone marrow transplantation: See: Bone marrow transplant.
Brain: That part of the central nervous system that is located within the cranium ( skull ). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called "hemispheres."
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Bruise: A bruise or "contusion" is an traumatic injury of the soft tissues which results in breakage of the local capillaries and leakage of red blood cells. In the skin it can be seen as a reddish-purple discoloration that does not blanch when pressed upon. When a bruise fades it becomes green and brown as the body metabolizes the blood cells in the skin. It is best treated with local application of a cold pack immediately after injury. Also called a contusion.
Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
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Catheter: A thin, flexible tube . For example, a catheter placed in a vein provides a pathway for giving drugs, nutrients, fluids, or blood products. Samples of blood can also be withdrawn through the catheter.
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Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane .
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Cerebrospinal fluid: CSF. A watery fluid, continuously produced and absorbed, which flows in the ventricles (cavities) within the brain and around the surface of the brain and spinal cord.
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Chemotherapy : 1. In the original sense, a chemical that binds to and specifically kills microbes or tumor cells. The term chemotherapy was coined in this regard by Paul Ehrlich (1854-1915).
2. In oncology, drug therapy for cancer. Also called "chemo" for short.
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Chest: The area of the body located between the neck and the abdomen . The chest contains the lungs , the heart and part of the aorta . The walls of the chest are supported by the dorsal vertebrae , the ribs , and the sternum .
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Chest X-ray: Commonly used to detect abnormalities in the lungs, but can also detect abnormalities in the heart, aorta, and the bones of the thoracic area. Metallic objects, such as jewelry are removed from the chest and neck areas for a chest x-ray to avoid interference with x-ray penetration and improve accuracy of the interpretation.
Childhood: (1) The time for a boy or girl from birth until he or she is an adult. (2) The more circumscribed period of time from infancy to the onset of puberty .
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Chromosomes: The microscopically visible carriers of the genetic material. They are composed of deoxyribonucleic acid (DNA) and proteins and, under a microscope, look like little rods.
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Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Chronic leukemia: Cancer of the blood cells (leukemia) that progresses slowly.
Chronic lymphocytic leukemia: See: Leukemia, chronic lymphocytic.
Chronic myelogenous leukemia: A chronic malignant disease in which too many white blood cells belonging to the myeloid line of cells are made in the bone marrow . Early symptoms of this form of leukemia include fatigue and night sweats . The disease is due to the growth and evolution of an abnormal clone of cells containing a chromosome rearrangement known as the Philadelphia (or Ph) chromosome. Chronic myelogenous leukemia is commonly called CML. It is also known as chronic myelocytic leukemia and chronic granulocytic leukemia.
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Chronic myeloid leukemia: See: Chronic myelogenous leukemia.
Clinical: 1. Having to do with the examination and treatment of patients. 2. Applicable to patients. A laboratory test may be of clinical value (of use to patients).
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Clinical trial: See: Clinical trials. See also: Inconclusive clinical trial; Negative clinical trial; Non-inferior clinical trial; Positive clinical trial.
Clinical trials: Trials to evaluate the effectiveness and safety of medications or medical devices by monitoring their effects on large groups of people.
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Cytogenetics: The study of chromosomes , the visible carriers of DNA , the hereditary material.
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Diagnosis: 1 The nature of a disease ; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies . 3 The identification of any problem. The diagnosis was a plugged IV.
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Diarrhea : A familiar phenomenon with unusually frequent or unusually liquid bowel movements, excessive watery evacuations of fecal material. The opposite of constipation . The word "diarrhea" with its odd spelling is a near steal from the Greek "diarrhoia" meaning "a flowing through." Plato and Aristotle may have had diarrhoia while today we have diarrhea. There are myriad infectious and noninfectious causes of diarrhea.
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Disease: Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.
Donor: The giver of a tissue or organ, for example, of blood or a kidney.
Down syndrome : A common chromosome disorder due to an extra chromosome number 21 (trisomy 21). Down syndrome causes mental retardation, a characteristic face, and multiple malformations. Down syndrome is a relatively common birth defect. The chromosome abnormality affects both the physical and intellectual development of the individual.
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Family: 1. A group of individuals related by blood or marriage or by a feeling of closeness. 2. A biological classification of related plants or animals that is a division below the order and above the genus. 3. A group of genes related in structure and in function that descended from an ancestral gene. 4. A group of gene products similarly related in structure and function and of shared genetic descent. 5. Parents and their children. The most fundamental social group in humans.
Fertility: The ability to conceive and have children, the ability to become pregnant through normal sexual activity. Infertility is defined as the failure to conceive after a year of regular intercourse without contraception.
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Formaldehyde: A pungent gas, with the chemical formula HCHO, used as an antiseptic, disinfectant, and especially today as a fixative for histology (the study of tissues under the microscope).
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Genetic: Having to do with genes and genetic information.
Graft-versus-host disease: A complication of bone marrow transplants in which T cells in the donor bone marrow graft go on the offensive and attack the host's tissues. Graft-versus-host disease (GVHD) is seen most often in cases where the blood marrow donor is unrelated to the patient or when the donor is related to the patient but not a perfect match. There are two forms of GVHD: an early form called acute GVHD that occurs soon after the transplant when the white cells are on the rise and a late form called chronic GVHD.
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GVHD: Graft-versus-host disease.
Hair loss : Hair loss is the thinning of hair on the scalp. The medical term for hair loss is alopecia . Alopecia can be temporary or permanent. The most common form of hair loss occurs gradually and is referred to as “androgenetic alopecia,” meaning that a combination of hormones (androgens are male hormones) and heredity ( genetics ) is needed to develop the condition. Other types of hair loss include alopecia areata (patches of baldness that usually grow back), telogen effluvium (rapid shedding after childbirth, fever , or sudden weight loss); and traction alopecia (thinning from tight braids or ponytails).
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Hairy cell leukemia: A form of chronic leukemia in which malignant B-lymphocytes (a type of white blood cell ) are seen in the bone marrow , spleen , and peripheral blood and when viewed under the microscope, these cells appear to be covered with tiny hair-like projections. Hairy cell leukemia represents 2% of all leukemia.
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Headache : A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes.
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Health: As officially defined by the World Health Organization, a state of complete physical, mental, and social well-being, not merely the absence of disease or infirmity.
Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Hemoglobin: The oxygen-carrying pigment and predominant protein in the red blood cells . Hemoglobin forms an unstable, reversible bond with oxygen. In its oxygenated state it is called oxyhemoglobin and is bright red. In the reduced state it is called deoxyhemoglobin and is purple-blue.
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Hospital: It may seem unnecessary to define a "hospital" since everyone knows the nature of a hospital. A hospital began as a charitable institution for the needy, aged, infirm, or young.
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Hot flashes: A sudden wave of mild or intense body heat caused by rushes of hormonal changes resulting from decreased levels of estrogen . Hot flashes can occur at any time and may last from a few seconds to a half-hour. They are due to blood vessel opening and constricting and a symptom of menopause .
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HTLV-I: Human T-lymphotropic virus type I, often referred to simply as the human T-lymphotropic virus ( HTLV ).
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Immune: Protected against infection. The Latin immunis means free, exempt.
Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Infertile: Not able to conceive after a year of regular intercourse without contraception.
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Injure: To harm, hurt, or wound. The word injure may be in physical or emotional sense. Treadmill machines may injure anyone who gets on one. Sexual molestation injures children. From the Latin injuria meaning injury.
Interferon : A naturally occurring substance that interferes with the ability of viruses to reproduce. Interferon also boosts the immune system.
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Intrathecal chemotherapy: Treatment with drugs that are injected into the fluid surrounding the brain and spinal cord (cerebrospinal fluid).
Irradiation: The use of high-energy radiation from x-rays, gamma rays, neutrons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy) or from materials called radioisotopes. Radioisotopes produce radiation and can be placed in or near the tumor or in the area near cancer cells. This type of radiation treatment is called internal radiation therapy, implant radiation, interstitial radiation, or brachytherapy. Systemic radiation therapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that circulates throughout the body. Irradiation is also called radiation therapy, radiotherapy, and x-ray therapy.
Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."
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Leukemia : Cancer of the blood cells. The growth and development of the blood cells are abnormal. Strictly speaking, leukemia should refer only to cancer of the white blood cells (the leukocytes) but in practice it can apply to malignancy of any cellular element in the blood or bone marrow, as in red cell leukemia (erythroleukemia).
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Lip: One of the two fleshy folds which surround the opening of the mouth.
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Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.
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Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung.
Lymph: An almost colorless fluid that travels through vessels called lymphatics in the lymphatic system and carries cells that help fight infection and disease.
Lymphocytic: Referring to lymphocytes, a type of white blood cell.
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Lymphoid: Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop.
Maintenance therapy: Treatment designed to help the original primary treatment succeed. Maintenance chemotherapy may be given to patients with cancer in remission to prevent a relapse.
Marrow: The bone marrow.
Medical history: 1. In clinical medicine, the patient's past and present which may contain clues bearing on their health past, present, and future. The medical history, being an account of all medical events and problems a person has experienced, including psychiatric illness, is especially helpful when a differential diagnosis is needed.
2. The history of medicine.
Medical school: A school with a curriculum leading to a medical degree. The mission of every medical school includes medical teaching, research, and patient care. All medical schools share the goal of preparing students in the art and science of medicine, and providing them with the background necessary to enter the period of graduate medical education. The years of medical school preceding graduate medical education are typically divided into a preclinical phase and a clinical phase.
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Menopause : The time in a woman's life when menstrual periods permanently stop; it is also called the "change of life." Menopause is the opposite of the menarche.
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Menstrual: Pertaining to menstruation (the menses), as in last menstrual period, menstrual cramps, menstrual cycle, and premenstrual syndrome. From the Latin menstrualis, from mensis meaning month.
Microscope: An optical instrument that augments the power of the eye to see small objects. The name microscope was coined by Johannes Faber (1574-1629) who in 1628 borrowed from the Greek to combined micro-, small with skopein, to view. Although the first microscopes were simple microscopes, most (if not all) optical microscopes today are compound microscopes.
Monoclonal: Pertaining to a single clone of cells, a single cell and the progeny of that cell. As opposed to polyclonal.
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Monoclonal antibody: An antibody produced by a single clone of cells (specifically, a single clone of hybridoma cells) and therefore a single pure homogeneous type of antibody. Monoclonal antibodies can be made in large amounts in the laboratory and are a cornerstone of immunology. The term "monoclonal" pertains to a single clone of cells, a single cell and the progeny of that cell.
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Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.
Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."
Myelodysplastic syndrome: A group of bone marrow disorders characterized by the underproduction of one or more types of blood cells due to dysfuntion of the marrow . The myelodysplastic syndromes (MDS) may arise de novo (newly) or be secondary to treatment with chemotherapy or radiation therapy for another disease. De novo myelodysplasia usually has a better prognosis than does secondary myelodysplasia.
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Myelogenous: Referring to the nonlymphocytic groups of white blood cells , including the granulocytes , monocytes and platelets .
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Myeloid: Referring to the nonlymphocytic groups of white blood cells , including the granulocytes , monocytes and platelets .
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Nausea: Nausea is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease.
Neck: The part of the body joining the head to the shoulders. Also, any narrow or constricted part of a bone or organ that joins its parts as, for example, the neck of the femur bone.
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Night sweats: Severe hot flashes which occur at night and result in a drenching sweat. Night sweats can have many different causes including medications, infections, and cancers.
NIH: The National Institutes of Health. The NIH is an important U.S. health agency. It is devoted to medical research. Administratively under the Department of Health and Human Services (HHS), the NIH consists of 20-some separate Institutes and Centers. NIH's program activities are represented by these Institutes and Centers.
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Nutrition : 1) The science or practice of taking in and utilizing foods. 2) A nourishing substance, such as nutritional solutions delivered to hospitalized patients via an IV or IG tube.
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Ommaya reservoir: A device implanted under the scalp that is used to deliver anticancer drugs to the cerebrospinal fluid, the fluid surrounding the brain and spinal cord. The device is named for the U.S. neurosurgeon Ayub Ommaya.
Outpatient: A patient who is not an inpatient (not hospitalized) but instead is cared for elsewhere -- as in a doctor's office, clinic, or day surgery center. The term outpatient dates back at least to 1715. Outpatient care today is also called ambulatory care.
Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life.
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Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Palliative care: 1) Medical or comfort care that reduces the severity of a disease or slows its progress rather than providing a cure. For incurable diseases, in cases where the cure is not recommended due to other health concerns, and when the patient does not wish to pursue a cure, palliative care becomes the focus of treatment. For example, if surgery cannot be performed to remove a tumor, radiation treatment might be tried to reduce its rate of growth, and pain management could help the patient manage physical symptoms. 2) In a negative sense, provision only of perfunctory health care when a cure is possible.
Pathologist: A doctor who identifies diseases by studying cells and tissues under a microscope.
Pediatric: Pertaining to children.
Peripheral: Situated away from the center, as opposed to centrally located.
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Peripheral blood stem cell transplantation: A new technique in which stem cells are obtained from a patient's blood and used in bone marrow transplantation.
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Platelet: An irregular, disc-shaped element in the blood that assists in blood clotting. During normal blood clotting, the platelets clump together (aggregate). Although platelets are often classed as blood cells, they are actually fragments of large bone marrow cells called megakaryocytes.
Protein: A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein.
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Quality of life: An important consideration in medical care, quality of life refers to the patient's ability to enjoy normal life activities. Some medical treatments can seriously impair quality of life without providing appreciable benefit, while others greatly enhance quality of life.
Radiation: 1. Rays of energy. Gamma rays and X-rays are two of the types of energy waves often used in medicine. 2. The use of energy waves to diagnose or treat disease. See also: Irradiation.
Radiation therapy : The use of high-energy rays to damage cancer cells, stopping them from growing and dividing. Like surgery, radiation therapy is a local treatment that affects cancer cells only in the treated area.
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Radiotherapy: The treatment of disease with ionizing radiation. Also called radiation therapy .
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Red blood cells: The blood cells that carry oxygen. Red cells contain hemoglobin and it is the hemoglobin which permits them to transport oxygen (and carbon dioxide). Hemoglobin, aside from being a transport molecule, is a pigment. It gives the cells their red color (and their name).
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Referral: The recommendation of a medical or paramedical professional. If you get a referral to ophthalmology, for example, you are being sent to the eye doctor. In HMOs and other managed care schemes, a referral is usually necessary to see any practitioner or specialist other than your primary care physician (PCP), if you want the service to be covered. The referral is obtained from your PCP, who may require a telephone or office consultation first.
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Relapse: The return of signs and symptoms of a disease after a patient has enjoyed a remission . For example, after treatment a patient with cancer of the colon went into remission with no sign or symptom of the tumor, remained in remission for 4 years, but then suffered a relapse and had to be treated once again for colon cancer.
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Remission: Disappearance of the signs and symptoms of cancer or other disease. When this happens, the disease is said to be "in remission." A remission can be temporary or permanent.
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Reservoir: 1. A place where something such as water is kept in reserve.
2. The part of a device in which something is kept in reserve or stored, as an Ommaya reservoir.
3. For an infectious agent, an animal, person, plant, soil, or other substance in which the agent normally abides. See: Reservoir of infection.
From the French réservoir, from réserver meaning to reserve.
Risk factor: Something that increases a person's chances of developing a disease.
Section: 1) In anatomy, a slice of tissue. A biopsy obtained by surgery is usually sectioned (sliced), and these sections are inspected under a microscope. 2) In obstetrics, short for Caesarian section. 3) In surgery, the division of tissue during an operation.
Shock: In medicine, shock is a critical condition brought on by a sudden drop in blood flow through the body. There is failure of the circulatory system to maintain adequate blood flow. This sharply curtails the delivery of oxygen and nutrients to vital organs. It also compromises the kidney and so curtails the removal of wastes from the body. Shock can be due to a number of different mechanisms including not enough blood volume (hypovolemic shock) and not enough output of blood by the heart (cardiogenic shock). The signs and symptoms of shock include low blood pressure (hypotension), overbreathing (hyperventilation), a weak rapid pulse, cold clammy grayish-bluish (cyanotic) skin, decreased urine flow (oliguria), and mental changes (a sense of great anxiety and foreboding, confusion and, sometimes, combativeness).
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Side effects: Problems that occur when treatment goes beyond the desired effect. Or problems that occur in addition to the desired therapeutic effect.
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Skin: The skin is the body's outer covering. It protects us against heat and light, injury, and infection. It regulates body temperature and stores water, fat, and vitamin D. Weighing about 6 pounds, the skin is the body's largest organ. It is made up of two main layers; the outer epidermis and the inner dermis.
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Sperm: A sperm is the male "gamete" or sex cell. It combines with the female "gamete," called an ovum, to form a zygote. The formation process is called "fertilization." (see ovum, zygote).
Spinal cord: The major column of nerve tissue that is connected to the brain and lies within the vertebral canal and from which the spinal nerves emerge. Thirty-one pairs of spinal nerves originate in the spinal cord: 8 cervical , 12 thoracic , 5 lumbar, 5 sacral, and 1 coccygeal. The spinal cord and the brain constitute the central nervous system ( CNS ). The spinal cord consists of nerve fibers that transmit impulses to and from the brain. Like the brain, the spinal cord is covered by three connective-tissue envelopes called the meninges . The space between the outer and middle envelopes is filled with cerebrospinal fluid ( CSF ), a clear colorless fluid that cushions the spinal cord against jarring shock. Also known simply as the cord.
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Spinal tap: Also known as a lumbar puncture or "LP", a spinal tap is a procedure whereby spinal fluid is removed from the spinal canal for the purpose of diagnostic testing. It is particularly helpful in the diagnosis of inflammatory diseases of the central nervous system, especially infections, such as meningitis. It can also provide clues to the diagnosis of stroke , spinal cord tumor and cancer in the central nervous system.
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Spine: 1) The column of bone known as the vertebral column, which surrounds and protects the spinal cord. The spine can be categorized according to level of the body: i.e., cervical spine (neck), thoracic spine (upper and middle back), and lumbar spine (lower back). See also vertebral column. 2) Any short prominence of bone. The spines of the vertebrae protrude at the base of the back of the neck and in the middle of the back. These spines protect the spinal cord from injury from behind.
Spleen: An organ located in the upper left part of the abdomen near the stomach . The spleen produces lymphocytes ; it is the largest lymphatic organ in the body. The spleen also filters the blood, serves as a major reservoir for blood and destroys blood cells that are aged.
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Stem cell: One of the human body's master cells, with the ability to grow into any one of the body's more than 200 cell types.
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Stem cell transplantation: The use of stem cells as a treatment for cancer or other diseases: - The stem cells are removed (or obtained) from a donor.
- Before a transplant is done for cancer, the patient receives high-dose chemotherapy and/or radiation to destroy the malignant cells.
- The stem cells are then given to the patient in whom they can produce new blood and immune cells and replace the cells destroyed by the treatment.
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Stress: Forces from the outside world impinging on the individual. Stress is a normal part of life that can help us learn and grow. Conversely, stress can cause us significant problems.
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Substance: 1. Material with particular features, as a pressor substance.
2. The material that makes up an organ or structure. Also known in medicine as the substantia.
3. A psychoactive drug as, for example, in substance abuse.
Supportive care: Treatment given to prevent, control, or relieve complications and side effects and to improve the patient's comfort and quality of life.
Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
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Symptom: Any subjective evidence of disease. Anxiety, lower back pain, and fatigue are all symptoms. They are sensations only the patient can perceive. In contrast, a sign is objective evidence of disease. A bloody nose is a sign. It is evident to the patient, doctor, nurse and other observers.
Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
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T-cell leukemia: A disease in which certain cells of the lymphoid system called T lymphocytes or T cells are malignant. T cells are white blood cells that normally can attack virus-infected cells, foreign cells, and cancer cells and produce substances that regulate the immune response.
Taste: Taste belongs to our chemical sensing system, or the chemosenses. The complicated process of tasting begins when molecules released by the substances stimulate special cells in the mouth or throat. These special sensory cells transmit messages through nerves to the brain where specific tastes are identified.
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Testicles: The testicles (also called testes or gonads) are the male sex glands. They are located behind the penis in a pouch of skin called the scrotum. The testicles produce and store sperm, and they are also the body's main source of male hormones (testosterone). These hormones control the development of the reproductive organs and other male characteristics, such as body and facial hair, low voice, and wide shoulders.
Therapy: The treatment of disease .
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Tired: A feeling of a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a sense of weariness and fatigue.
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Tissue: A tissue in medicine is not like a piece of tissue paper. It is a broad term that is applied to any group of cells that perform specific functions. A tissue in medicine need not form a layer. Thus, - The bone marrow is a tissue;
- Connective tissue consists of cells that make up fibers in the framework supporting other body tissues; and
- Lymphoid tissue is the part of the body's immune system that helps protect it from bacteria and other foreign entities.
Transplant: The grafting of a tissue from one place to another, just as in botany a bud from one plant might be grafted onto the stem of another. The transplanting of tissue can be from one part of the patient to another (autologous transplantation), as in the case of a skin graft using the patient's own skin; or from one patient to another (allogenic transplantation), as in the case of transplanting a donor kidney into a recipient.
Twin: One of two children produced in the same pregnancy and born during the same birth process.
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Umbilical cord: The cord that connects the developing embryo or fetus with the placenta and through which run the umbilical arteries and vein. The matrix (the substance) of the umbilical cord is known as Wharton's jelly and is a rich source of stem cells. At birth the umbilical cord measures about 20 inches (50 cm) in length. The cord is clamped and cut after birth and its residual tip forms the umbilicus (bellybutton).
Vein: A blood vessel that carries blood low in oxygen content from the body back to the heart. The deoxygenated form of hemoglobin (deoxyhemoglobin) in venous blood makes it appear dark. Veins are part of the afferent wing of the circulatory system which returns blood to the heart.
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Virus: A microorganism smaller than a bacteria, which cannot grow or reproduce apart from a living cell. A virus invades living cells and uses their chemical machinery to keep itself alive and to replicate itself. It may reproduce with fidelity or with errors (mutations)-this ability to mutate is responsible for the ability of some viruses to change slightly in each infected person, making treatment more difficult.
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Watchful waiting: Closely monitoring a patient's condition but withholding therapy until the sign and symptom appear or change. Also called observation.
Weight loss: Weight loss is a decrease in body weight resulting from either voluntary (diet, exercise) or involuntary (illness) circumstances. Most instances of weight loss arise due to the loss of body fat, but in cases of extreme or severe weight loss, protein and other substances in the body can also be depleted. Examples of involuntary weight loss include the weight loss associated with cancer, malabsorption (such as from chronic diarrheal illnesses ), and chronic inflammation (such as with rheumatoid arthritis).
White blood cell: One of the cells the body makes to help fight infections. There are several types of white blood cells ( leukocytes ). The two most common types are the lymphocytes and neutrophils (also called polymorphonuclear leukocytes, PMNs, or "polys").
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X-ray: 1. High-energy radiation with waves shorter than those of visible light. X-rays possess the properties of penetrating most substances (to varying extents), of acting on a photographic film or plate (permitting radiography), and of causing a fluorescent screen to give off light (permitting fluoroscopy). In low doses X-rays are used for making images that help to diagnose disease, and in high doses to treat cancer . Formerly called a Roentgen ray. 2. An image obtained by means of X-rays.
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